I-40
I-40 East or West to exit #44. Turn right to exit, Holiday Inn - Biltmore West is one block on the right.

I-26 and Asheville Regional Airport
I-26 West to I-40 West. I-40 West to exit #44. Turn right off exit, Holiday Inn - Biltmore West is one block on the right.

Highway 19/23
Highway 19/23 South to I-240 West. I-240 West to I-40 West. I-40 West to exit #44. Turn right off exit, Holiday Inn - Biltmore West is one block on the right.